Active metabolite of alpha methyldopa. Acts on the central alpha 2 adrenergic receptors to decrease central sympathetic outflow. Precursor form – alpha methyldopa – is used as an antihypertensive.

1. Methyldopa
2. Clonidine
3. Alpha-2 adrenergic receptor – Location, Actions, Agonist, Antagonists
4. Mechanism of action of fibrates