It is a set of 4 conditions as set by the Harvard School of Medicine for diagnosis of irreversible coma. They are:

• Unreceptivity and unresponsiveness
• Lack of movements or breathing
• Absent reflexes
• Flat electroencephalogram (confirmatory)

These conditions also are to be met:

• Body temperature >= 32 C
• Not under the influence of CNS depressants 

1. Evening rise of temperature
2. Types of brain death
3. Mechanism of febrile seizures
4. Episcleritis – Etiopathogenesis, Clinical features, Treatment