• derivatives of fibric acid (isobutyric acid)
• activate Peroxisome Proliferator Activated Receptor alpha (PPAR) – a gene transcription regulating receptor present in liver, fat and muscles

Activation of PPAR alpha results in:

• increased synthesis of lipoprotein lipase – hydrolyse triglycerides – decrease circulating TG’s
• increased expression of LDL receptor in liver – mainly with II generation fibrates
• increased fatty acid oxidation
• decrease TG synthesis in liver
•  reduce circulating free fatty acids

Outcome:

• decrease TG 20-50%
• decrease LDL 10-15%
• increase HDL 10-15%

1. Fatty change
2. Hypolipidemic drugs
3. Lipoprotein lipase
4. Lipid transport in blood