It is loop diuretic acting on Na+ K+ 2Cl- Co-transporter in thick ascending limb of loop of Henle.

Torsemide vs Frusemide

• 3 times more potent
• better oral bioavailability
• absorbed more rapidly when given orally
• longer T1/2 (3.5 hrs)
• longer duration of action (4-8 hrs)

Indications

• Edema
• Hypertension

Dose

• 2.5-5mg OD in hypertension
• 5-20mg/day in edema
• upto 100mg BD in renal failure

1. Loop Diuretics
2. Frusemide
3. Bumetanide
4. Frusemide – Onset of action